{"id":152315,"date":"2024-08-01T09:07:32","date_gmt":"2024-08-01T13:07:32","guid":{"rendered":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/?p=152315"},"modified":"2024-08-01T09:12:41","modified_gmt":"2024-08-01T13:12:41","slug":"the-science-and-humanity-behind-giving-the-gift-of-life","status":"publish","type":"post","link":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/","title":{"rendered":"The science and humanity behind giving the gift of life"},"content":{"rendered":"<p class=\"p6\"><span class=\"s3\"><a href=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/life-connection-building\/\" rel=\"attachment wp-att-152348\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-152348\" src=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/files\/2024\/07\/Life-Connection-Building-508x339.jpg\" alt=\"\" width=\"460\" height=\"307\" \/><\/a>As sciences go, organ transplants are relatively new. The first kidney transplant was in 1954; the first liver, 1963; the first heart, 1967.<\/span><\/p>\n<p class=\"p8\">\u201cIt\u2019s not an old science,\u201d Matthew Wadsworth said in reflection.<\/p>\n<p class=\"p8\">Organ transplantation is Wadsworth\u2019s profession\u2014not as a doctor, but in a wider sense. The 2007 Wright State University biology graduate is chief executive officer of Life Connection of Ohio, a nonprofit based in Kettering that is the organ procurement organization for the northwest and west-central parts of the state.<\/p>\n<p class=\"p8\">Life Connection promotes organ-donor registration, medically manages organ donors in hospitals\u2019 intensive care units, and approaches families of those who aren\u2019t registered but, because of their condition, are potential immediate donors. It began in 1989 with the merger of two other nonprofits that focused on kidney transplants.<\/p>\n<p class=\"p8\">Since then, Life Connection\u2014and transplantation in general\u2014has widened its scope to include, as Wadsworth said, \u201clungs, pancreas, intestines, tissue, heart valves, bones, tendons.\u201d<\/p>\n<p class=\"p8\">He said when he arrived in 2020 that Life Connection was ranked 48th among the 57 ODOs nationwide in donation and transplant rates. The most recent figures show that Life Connection is now No. 1.<\/p>\n<p class=\"p8\">The rise in transplants is possible because of advances in immunosuppressants, anti-rejection drugs\u2014that prevent the body\u2019s immune system from fighting off the new organ. \u201cI would add that growth has occurred not only due to immunosuppression, but also adoption of pump technology and expansion of the organ donor pool into older patients,\u201d Wadsworth said.<\/p>\n<p class=\"p8\">Attesting to that change is Liz Cridlin, Life Connection\u2019s development specialist and a 2013 Wright State graduate in biological sciences. Early in her time with the nonprofit, she was its procurement transplant coordinator. At that time, \u201cwe weren\u2019t recovering livers from people with hepatitis C,\u201d she said. \u201cNow, that\u2019s really common because we have come so far in medicine.\u201d Cridlin explained that a donor can be treated for the disease, or the recipient can be treated before receiving the liver and doesn\u2019t get the disease.<\/p>\n<p class=\"p8\">\u201cWe\u2019re able to recover more organs from a population we weren\u2019t before,\u201d she said. \u201cSo, there\u2019s a bigger pool of people who are able to donate.\u201d<\/p>\n<h3 class=\"p8\"><strong>The human factor<\/strong><\/h3>\n<div id=\"attachment_152356\" style=\"width: 238px\" class=\"wp-caption alignright\"><a href=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/liz-cridlin-organ-donation\/\" rel=\"attachment wp-att-152356\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-152356\" class=\"size-medium wp-image-152356\" src=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/files\/2024\/07\/Liz-Cridlin-Organ-Donation-228x300.jpg\" alt=\"\" width=\"228\" height=\"300\" \/><\/a><p id=\"caption-attachment-152356\" class=\"wp-caption-text\">Liz Cridlin &#8217;13<\/p><\/div>\n<p class=\"p8\">\u201cPeople\u201d is a key word, because, while transplanting organs is very much a science, the human factor is paramount.<\/p>\n<p class=\"p8\">Life Connection cares for and supports the family of a donor, Wadsworth said. Registering as an organ donor \u201ctakes stress off the family to make a decision,\u201d he said. Or a family may not know that their loved one who has died or is on ventilator or mechanical support is a donor.<\/p>\n<p class=\"p8\">\u201cOrgan donation can help a family heal,\u201d he said, \u201cknowing that a loved one saved a life, or many lives. This gives them comfort in such a terrible situation.\u201d<\/p>\n<p class=\"p8\">\u201cOne person has the power to save eight lives through organ donation and heal 125 more through tissue donation,\u201d said Stephanie Burianek, Life Connection\u2019s community outreach coordinator and a 2008 Wright State graduate in mass communication.<\/p>\n<p class=\"p8\">\u201cEvery 10 minutes, another person is added to the national transplant waiting list,\u201d she said. Nationally, 20 people die each day waiting for an organ, she said.<\/p>\n<p class=\"p8\">Cridlin develops and helps train Life Connection\u2019s staff of more than 100 to make the donor procedure go properly and smoothly. They\u2019re assembled into three groups, as she explained:<\/p>\n<ul>\n<li class=\"p8\">Hospital development specialists, \u201cthe bridge between Life Connection and the hospitals,\u201d she said. These specialists educate the hospital staff and follow the hospital\u2019s policy and regulations regarding potential donor patients.<\/li>\n<li class=\"p8\">Organ recovery coordinators, responsible for the medical management of a patient, matching the donor with the recipient, and ensuring the organs are recovered and transported appropriately.<\/li>\n<li class=\"p8\">Family service coordinators, who speak with families at the time of their loved one\u2019s death to give support and ensure they have all the information and appropriate paperwork.<\/li>\n<\/ul>\n<p class=\"p8\">Cridlin added that she also trains the nonprofit\u2019s clinical staff, \u201cso they have a well-rounded overview of the science of organ transplants.\u201d<\/p>\n<h3 class=\"p8\"><strong>Debunking myths<\/strong><\/h3>\n<p class=\"p8\">Apart from the science, myths surround organ transplants. Burianek debunks them.<\/p>\n<p class=\"p8\">\u201cNumber one, people ask, \u2018will doctors save my life?\u2019<\/p>\n<p class=\"p8\">They\u2019re worried that if a doctor knows they\u2019re a donor, a doctor won\u2019t do everything to help.\u201d Burianek said unequivocally, \u201cAbsolutely they will do everything to save you.\u201d She added that only after all life-saving options are exhausted will Life Connection enter the situation.<\/p>\n<p class=\"p8\">\u201cNumber two, people are worried about the cost; will they get billed?\u201d<\/p>\n<div id=\"attachment_152359\" style=\"width: 224px\" class=\"wp-caption alignright\"><a href=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/stephanie-burianek\/\" rel=\"attachment wp-att-152359\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-152359\" class=\"size-medium wp-image-152359\" src=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/files\/2024\/07\/Stephanie-Burianek-214x300.jpg\" alt=\"\" width=\"214\" height=\"300\" \/><\/a><p id=\"caption-attachment-152359\" class=\"wp-caption-text\">Stephanie Burianek &#8217;08<\/p><\/div>\n<p class=\"p8\">She emphasized, \u201cThere\u2019s no cost to the donor family. All costs associated with donation are the responsibility of the organ and tissue organizations.\u201d The hospital\u2019s charge ends after death is declared.<\/p>\n<p class=\"p8\">\u201cNumber three, people ask if they\u2019re too old or too sick to donate. We say, don\u2019t judge a book by its cover; let us be the ones to judge. People with a history of diabetes, cancer, or other conditions can still give the gift of life, such as tissue or corneas.\u201d She added that the oldest organ donor on record was 95.<\/p>\n<p class=\"p8\">\u201cNumber four is religion\u2014people wonder whether their religion is against organ donation.\u201d<\/p>\n<p class=\"p8\">She said most religions encourage donations \u201cas the last act of charity, to give the gift of life, and leave it up to the individual.\u201d<\/p>\n<h3 class=\"p8\"><strong>Glimpse of the future<\/strong><\/h3>\n<p class=\"p8\">Transplant science is evolving. Wadsworth said, in the past year, progress has been made in genetically modifying pigs to use their kidneys in humans. Also being developed is cryopreservation\u2014the rapid freezing and reheating of an organ, leaving it undamaged.<\/p>\n<p class=\"p8\">The thought is to grow genetically modified kidneys in pigs, cryopreserve them, then reheat them when needed to transplant into a person. \u201cThat\u2019s the direction we\u2019re going,\u201d he said.<\/p>\n<p class=\"p8\">A direction that\u2019s current yet advancing is organ preservation technology, which keeps a removed organ viable longer than otherwise possible.<\/p>\n<p class=\"p8\">\u201cWe\u2019re able to recover and keep organs outside the body longer for recipients farther away,\u201d Cridlin said.<\/p>\n<p class=\"p8\">One such device is in the works thanks to an entrepreneur with a Wright State connection. Klaus Weiswurm enrolled in the university\u2019s systems engineering program in 1969, attended classes part time, and in 1976 moved to Texas, where he completed his education.<\/p>\n<p class=\"p8\">The device he and his associates are championing is called ENCORE. It keeps a donor heart secure and filled with a liquid to keep the cells oxygenated and uses a diaphragm pump to put pressure on the organ, making it viable longer, Weiswurm explained. \u201cIt mimics the function of the organ in the human body.\u201d<\/p>\n<p class=\"p8\">He said it passed trials in animals in 2023 and is expected to go into human trials this year, possibly securing Federal Food and Drug Administration approval in 2025.<\/p>\n<p class=\"p8\">He said what sets ENCORE apart from other such devices is it\u2019s less expensive, constantly providing fresh oxygen to the organ, and is comparatively small. \u201cIt can fit into a suitcase and go into an overhead bin on an airplane,\u201d which means it can be transported on a commercial airline to get it to anywhere in the world.<\/p>\n<div id=\"attachment_152349\" style=\"width: 470px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/life-connection-wall-art-2\/\" rel=\"attachment wp-att-152349\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-152349\" class=\"size-large wp-image-152349\" src=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/files\/2024\/07\/Life-Connection-wall-art-2-508x297.jpg\" alt=\"\" width=\"460\" height=\"269\" \/><\/a><p id=\"caption-attachment-152349\" class=\"wp-caption-text\">Donor Hero Homage art pieces hanging in the hallways at Life Connection of Ohio. This display was created using personal objects from organ donors.<\/p><\/div>\n<h3 class=\"p8\"><strong>Have the talk<\/strong><\/h3>\n<p class=\"p8\">\u201cOverall, society has a pretty positive opinion of organ donation,\u201d Cridlin said. She\u2019s found that many people are willing to be a donor because \u201cthey say, \u2018I\u2019ll be gone, so if I can help someone else, that\u2019s great.\u2019 What we lack is talking about organ donation with our family members or legal next of kin. We don\u2019t talk about death.\u201d<\/p>\n<p class=\"p8\">Life Connection \u201cencourages people to share their decision of being an organ donor with their families,\u201d she said.<\/p>\n<p class=\"p8\">\u201cIt is a little scary to discuss,\u201d Burianek said, \u201cbut crucial. It\u2019s always good to have those uncomfortable conversations early on to make that decision.\u201d<\/p>\n<p class=\"p8\">Burianek said Life Connection stands ready \u201cso people get the right information, not hearsay\u2014to get the facts about organ donation so they can make an educated decision.\u201d<\/p>\n<p class=\"p8\">Cridlin said the donation process is, \u201cthe silver lining in what is always a tragic situation. These families have gone through a tragic event. A lot of the time, they find comfort that their loved ones were organ donors.<\/p>\n<p class=\"p8\">\u201cI\u2019ve worked with a lot of families in this situation,\u201d Cridlin concluded, \u201cand every family in my 10 years was thankful they went through the process for donation. It\u2019s hard to put into words, but it provides such a comfort to them when their loved one is able to save somebody else\u2019s life.\u201d<\/p>\n<p class=\"p1\"><span class=\"s1\"><i>This article was originally published in the 2024 issue of the Wright State Magazine. Read more stories at\u00a0<\/i><a href=\"http:\/\/wright.edu\/magazine\"><span class=\"s2\"><i>wright.edu\/magazine<\/i><\/span><\/a><i>.<\/i><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wright State University alumni play significant roles at Life Connection of Ohio, which is ranked No. 1 in organ donation and transplant rates nationally.\u00a0 <a href=\"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2024\/08\/01\/the-science-and-humanity-behind-giving-the-gift-of-life\/\" class=\"morelink\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":66,"featured_media":152348,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[722,733,4309,2064,725,747,4827,715,746,4855],"tags":[],"class_list":["post-152315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academics","category-alumni","category-alumni-association","category-biology","category-home-news-sidebar","category-liberal-arts","category-magazine","category-news","category-science-mathematics","category-social-sciences-and-international-studies"],"_links":{"self":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/152315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/users\/66"}],"replies":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/comments?post=152315"}],"version-history":[{"count":7,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/152315\/revisions"}],"predecessor-version":[{"id":152502,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/152315\/revisions\/152502"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media\/152348"}],"wp:attachment":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media?parent=152315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/categories?post=152315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/tags?post=152315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}