{"id":50276,"date":"2018-02-08T10:30:52","date_gmt":"2018-02-08T15:30:52","guid":{"rendered":"http:\/\/webapp2.wright.edu\/web1\/newsroom\/?p=50276"},"modified":"2018-02-08T11:08:04","modified_gmt":"2018-02-08T16:08:04","slug":"researchers-to-study-role-of-genes-in-new-treatments-for-deadly-pediatric-brain-tumor","status":"publish","type":"post","link":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2018\/02\/08\/researchers-to-study-role-of-genes-in-new-treatments-for-deadly-pediatric-brain-tumor\/","title":{"rendered":"Researchers to study role of genes in new treatments for deadly pediatric brain tumor"},"content":{"rendered":"
\"\"<\/a>

Robert Lober is a physician scientist and assistant professor of pediatrics at the Boonshoft School of Medicine.<\/p><\/div>\n

A team of researchers from the Wright State University Boonshoft School of Medicine<\/a> received an\u00a0award of $48,500 from the Mayfield Education & Research Foundation of Cincinnati to study the role of genes in new treatments for a deadly pediatric brain tumor.<\/p>\n

Led by Robert Lober, M.D., Ph.D., a physician scientist and assistant professor of pediatrics at the Boonshoft School of Medicine, the researchers are studying diffuse intrinsic pontine glioma (DIPG). DIPG is a highly aggressive brain tumor found at the base of the brain. Difficult to treat, it is a terminal form of childhood cancer. There is no surgical intervention, and clinical trials have been unsuccessful and ineffective.<\/p>\n

\u201cI treat children with brain tumors,\u201d said Lober, who practices at Dayton Children\u2019s Hospital. \u201cThis research directly addresses a particular incurable brain cancer in children. We are trying to understand how these tumors resist all current treatments through changes in gene expression.\u201d<\/p>\n

The one-year award will enable Lober and his research team to identify critical molecular mediators of DIPG treatment resistance and understand how gene expression affects tumor growth and treatment resistance.<\/p>\n

\u201cWe are seeking to gain a new understanding of preferential gene repression at critical loci as the foundation for studying ways in which treatment is resisted,\u201d Lober said. \u201cWe want to bring about a new paradigm of therapies based on tumor gene expression patterns.\u201d<\/p>\n

His team includes co-principal investigator Thomas Brown, Ph.D., associate chair for research; professor of neuroscience, cell biology and physiology; and professor of obstetrics and gynecology at the Boonshoft School of Medicine; Christopher Waker, a Wright State graduate student; and research assistants Chanel Keoni and Brianna Schurko of Dayton Children\u2019s.<\/p>\n

Through Dayton Children\u2019s affiliation with the Wright State University and Premier Health Neuroscience Institute<\/a>, Lober researches brain tumors in children through high-level imaging.<\/p>\n

The Mayfield Education & Research Foundation exists to advance the care of patients with brain and spine disorders through education and research.<\/p>\n","protected":false},"excerpt":{"rendered":"

The researchers are trying to understand how tumors caused by an incurable brain cancer in children resist all current treatments through changes in gene expression. Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":50,"featured_media":50282,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[722,711,725,4265,2016,2129,2115,715,18],"tags":[],"class_list":["post-50276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academics","category-faculty-staff","category-home-news-sidebar","category-research-medicine","category-medicine","category-neuroscience-institute","category-neuroscience-cell-biology-and-physiology","category-news","category-research"],"_links":{"self":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/50276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/comments?post=50276"}],"version-history":[{"count":9,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/50276\/revisions"}],"predecessor-version":[{"id":50301,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/50276\/revisions\/50301"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media\/50282"}],"wp:attachment":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media?parent=50276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/categories?post=50276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/tags?post=50276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}