{"id":55287,"date":"2018-12-11T09:23:22","date_gmt":"2018-12-11T14:23:22","guid":{"rendered":"http:\/\/webapp2.wright.edu\/web1\/newsroom\/?p=55287"},"modified":"2018-12-11T09:30:20","modified_gmt":"2018-12-11T14:30:20","slug":"muscle-mystery","status":"publish","type":"post","link":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/2018\/12\/11\/muscle-mystery\/","title":{"rendered":"Muscle mystery"},"content":{"rendered":"
\"\"<\/a>

Andrew Voss, associate professor of biology, received a federal grant to research Huntington\u2019s disease with his Wright State University students. (Photo by Erin Pence)<\/p><\/div>\n

A $454,967 federal research award will help associate biology<\/a> professor Andrew Voss and his Wright State University students investigate Huntington\u2019s disease, a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain and possibly skeletal muscle.<\/p>\n

Huntington\u2019s disease, which has no cure, deteriorates a person\u2019s physical and mental abilities during their prime working years. Today, there are about 30,000 symptomatic Americans and more than 200,000 at risk of inheriting the disease.<\/p>\n

The three-year research award from the National Institutes of Health\/National Institute of Neurological Disorders and Stroke is aimed at determining if there is a primary disease of the muscle in Huntington\u2019s disease.<\/p>\n

\u201cWe did find defects in the muscle of Huntington\u2019s disease mice,\u201d said Voss. \u201cBut the question is how much of that is due to a nerve degeneration versus how much of it is muscle itself? And do the muscle defects also feedback to the nervous system?\u201d<\/p>\n

Using the same tools that are used in gene therapy, Voss\u2019 students are inserting the mutant Huntington gene into skeletal muscle to determine the role of the mutant Huntington gene in skeletal muscle and how muscle signals back to nerves.<\/p>\n

The outcome of the research holds out the promise of paving the way for treatment of Huntington\u2019s. The other benefit may be an increased ability to assess and track the progression of the disease.<\/p>\n

Symptoms of Huntington\u2019s usually appear between the ages of 30 to 50 and worsen over a 10-to-25-year period. Ultimately, the weakened individual succumbs to pneumonia, heart failure or other complications.<\/p>\n

Voss\u2019 journey to Huntington\u2019s research was a winding road. He grew up in rural Minnesota and moved to Sacramento, California, when he was in junior high school. After graduating high school, he enrolled at the University of California-Davis, got interested in biology and then biochemistry.<\/p>\n

\u201cThe longer I was in biology the more I began to blend it with some of the physical sciences,\u201d he said. \u201cYou have biology with lots of variables and then you get the physical side, which gives you more of a concrete, repeatable picture.\u201d<\/p>\n

After earning his bachelor\u2019s degree in biochemistry in 1996, Voss taught chemistry and basic science at Hiram W. Johnson High School, an inner-city school in Sacramento.<\/p>\n

\u201cIt gave me a good appreciation for teaching and to see what kids in the inner city go through,\u201d he said. \u201cIt was all about my interaction with the kids, which was great. But I wanted to do more actual science.\u201d<\/p>\n

So in 2004, Voss returned to UC-Davis, earning his Ph.D. in pharmacology and toxicology. He then did postdoctoral work at UCLA\u2019s medical school, where his interest shifted to physiology.<\/p>\n

\u201cWhat I really liked was some of the electrophysiology \u2014 the electrical signals in a nerve and muscle,\u201d he said. \u201cI really liked the application of that technique.<\/p>\n

In 2009, he landed a faculty position at California Polytechnic State University in Pomona teaching human physiology. While he was teaching a graduate class, one of the students selected a primary research paper that examined neuromuscular junctions in Huntington\u2019s disease mice.<\/p>\n

\u201cI saw the data a little bit differently,\u201d Voss recalled. \u201cI hypothesized that there was actually a problem in the muscle, so I began conducting experiments with the mice and discovered that there was in fact a defect.\u201d<\/p>\n

The discovery led to a research paper on Huntington\u2019s and publication in a prestigious academic journal.<\/p>\n

Voss, who joined the faculty at Wright State in 2014, points out that the Huntington\u2019s research is being done by his undergraduate and graduate students.<\/p>\n

\u201cIt\u2019s important for them to be able to do the experiments,\u201d he said.<\/p>\n","protected":false},"excerpt":{"rendered":"

The three-year research award is aimed at determining if there is a primary disease of the muscle in Huntington\u2019s disease. Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":17,"featured_media":55293,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[722,2064,2023,2060,725,715,18,746],"tags":[],"class_list":["post-55287","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academics","category-biology","category-faculty","category-graduate","category-home-news-sidebar","category-news","category-research","category-science-mathematics"],"_links":{"self":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/55287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/comments?post=55287"}],"version-history":[{"count":8,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/55287\/revisions"}],"predecessor-version":[{"id":55298,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/posts\/55287\/revisions\/55298"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media\/55293"}],"wp:attachment":[{"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/media?parent=55287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/categories?post=55287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/webapp2.wright.edu\/web1\/newsroom\/wp-json\/wp\/v2\/tags?post=55287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}